WABI 2003


3rd Workshop on Algorithms in Bioinformatics
Budapest, Hungary, 15-20 September, 2003

                                 

                                                                                                                                                                                                                        

Contents
       
Call for Posters
       
Scope
       
Topics
       
Submission
       
Accepted Papers
        Program           
       
Important Dates
       
Program Committee
       
WABI Steering Committee
        Registration and Hotel Reservation Form

CALL FOR POSTER                                                                                                                                  

        A poster session will be organized during the workshop. The emphasis is on algorithmic work that addresses an important problem in molecular biology. Graduate students with significant work in progress are especially invited to submit posters. A printed version of the poster abstracts will be distributed at the workshop.

        Poster abstracts must be one or two pages long and must contain: the title; the authors and their addresses (including email addresses); a short abstract using 10 point font or larger and single line spacing.  A standard PDF file must be sent to Gary Benson (benson@camelot.mssm.edu), by July 25th, 2003. Authors will be notified about acceptance by August 1, 2003.

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SCOPE                                                                                                                                               

        The Workshop on Algorithms in Bioinformatics covers research in all aspects of algorithmic work in bioinformatics and computational biology. The emphasis is on discrete algorithms that address important problems in molecular biology, genomics and genetics, that are founded on sound models, that are computationally efficient, that have been implemented and tested in simulations and on real datasets and that provide new biological results. The goal is to present recent research results, including significant work-in-progress, and to identify and explore directions for future research.
  
     WABI 2003 will be held as part of ALGO 2003 in Budapest, Hungary, 15-20 September, 2003.

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TOPICS                                                                                                                                            

        Original research papers (including significant work-in-progress) or state-of-the-art surveys are solicited in all aspects of algorithms in bioinformatics and computational biology, including, but not limited to:                   

    * Exact and approximate algorithms for genomics, genetics, sequence analysis, gene and signal recognition, alignment, molecular evolution, phylogenetics, structure determination or prediction, gene expression and gene networks, proteomics, functional genomics, and drug design.

    * Methods, software and dataset repositories for development and testing of such algorithms and their underlying models.

    * High-performance computing approaches to computationally hard problems in bioinformatics, particularly optimization problems.                    

        The proceedings of the workshop will be published in the Lecture Notes in Computer Science (LNCS) series of Springer Verlag.

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SUBMISSIONS                                                                                                                                                                                            

        Submissions should consist of an extended abstract of no more than 15 pages (including title page, all figures and bibliography) in 11pt font, preferably using the Springer LNCS style (see: http://www.springer.de/comp/lncs/authors.html). An abstract should start with a presentation of the biological motivation, the algorithmic problem, the results achieved, their significance and a comparison with previous work. This material should be understandable to non-specialists. A more technical exposition should follow and an optional short appendix may contain details or additional data to be consulted at the discretion of the program committee. The submission must include the corresponding author's email address.  
  
     Submissions must be made using the online submission server at (http://wabi.biomath.mssm.edu).  Deadline is 23:59 (GMT) on 28 April 2003, for your submission to be considered. Three formats will be supported this year, postscript, pdf, and doc. Each submission must be submitted as a single file.  Authors using other than latex to generate their document are cautioned that as of the date of this call for papers, the final version of accepted papers must be submitted as a latex file.
  
     Simultaneous submission to another conference or journal is allowed. Authors are asked to inform the program co-chairs at the time of submission of the simultaneous submission. If the submission has been accepted to another conference or a journal before WABI 2003, the abstract will not be published in the proceedings of WABI 2003.
        In order to ensure inclusion of their work in the proceedings, authors must present their accepted papers at the workshop.

        Address any questions to the program committee co-chairs, Gary Benson (benson@camelot.mssm.edu) and Roderic Page (r.page@bio.gla.ac.uk).

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ACCEPTED PAPERS                                                                                                                                    

Consensus networks: A method for visualising incompatibilities in collections of trees

Barbara Holland, Vincent Moulton 

Parsimonious Reconstruction of Sequence Evolution and Haplotype Blocks: Finding the Minimum Number of Recombination Events

Yun Song, Jotun Hein

A Local Chaining Algorithm and its Applicationsin Comparative Genomics

Mohamed Ibrahim Abouelhoda, Enno Ohlebusch

Pattern discovery allowing gaps, substitution matrices and multiple score functions

Alban Mancheron, Irena Rusu 

A Combinatorial Approach to Automatic Discovery of Cluster-Patterns

Revital Eres, Gad Landau, Laxmi Parida 

Efficient Generation of Uniform Samples from Phylogenetic Trees

Paul Kearney, Ian Munro, Derek Phillips 

New Efficient Algorithm for Detection of Horizontal Gene Transfer Events

Alic Boc, Vladimir Makarenkov 

Side-chain Structure Prediction based on Dead-End Elimination: Single Split DEE-criterion Implementation and Elimination Power.

Jan Spriet, Niles Pierce, Johan Desmet, Stephen Mayo 

Efficient Energy Computation for Monte Carlo Simulation

Itay Lotan, Fabian Schwarzer, Jean-Claude Latombe 

Speedup LP Approach to Protein Threading via Graph Reduction

Jinbo Xu 

Match Chaining Algorithms for cDNA Mapping

Tetsuo Shibuya, Igor Kurochkin 

Identifying Blocks and Sub-Populations in Noisy SNP Data

Gad Kimmel, Roded Sharan, Ron Shamir

A stochastic approach to count RNA molecules using DNA sequencing methods

Boris Hollas, Rainer Schuler 

A Large Version of the Small Parsimony Problem

Jakob Fredslund, Jotun Hein, Tejs Scharling 

Designing Optimally Multiplexed SNP Genotyping Assays

Yonatan Aumann, Efrat Manisterski, Zohar Yakhini 

Ancestral Maximum Likelihood of Phylogenetic Trees is Hard

Louigi Addario-Berry, Benny Chor, Mike Hallett, Jens Lagergren, Alessandro Panconesi, Tod Wareham
 

A systematic statistical analysis of ion trap tandem mass spectra in view of peptide scoring

Jacques Colinge, Alexandre Masselot, Jerome Magnin

Vector seeds: an extension to spaced seeds allows substantial improvements in sensitivity and specificity

Brona Brejova, Daniel Brown, Tomas Vinar 

New Algorithm for the Simplified Partial Digest Problem

Jacek Baewicz, Marcin Jaroszewski 

A Linear-time Majority Tree Algorithm

Nina Amenta, Frederick Clarke, Katherine St. John 

Common intervals of two sequences

Gilles Didier 

Sequencing from compomers: Using mass spectrometry for DNA de-novo sequencing of 200+ nt

Sebastian Boecker 

Bayesian phylogenetic inference under a statistical insertion--deletion model

Gerton Lunter, Istvan Miklos, Jens Ledet Jensen, Alexei Drummond 

Bounds for Resequencing By Hybridization

Dekel Tsur 

Noisy Data Make the Partial Digest Problem NP-hard

Mark Cieliebak, Stephan Eidenbenz, Paolo Penna 

Better hill-climbing searches for parsimony

Ganeshkumar Ganapathy, Vijaya Ramachandran, Tandy Warnow 

Optimal Multiple Parsimony Alignment with Affine Gap Cost Using a Phylogenetic Tree

Bjarne Knudsen 

Minimum Recombinant Haplotype Configuration on Pedigrees without Mating Loops

Koichiro Doi, Jing Li, Tao Jiang 

Dynamic Programming Algorithms for Two Statistical Problems in Computational Biology

Sven Rahmann 

Computing Refined Buneman Trees in Cubic Time

Gerth Stolting, Rolf Fagerberg, Anna Ostlin, Christian N. S. Pedersen, S. Srinivasa Rao 

Composition Alignment

Gary Benson 

Phylogenetic Analysis of Recombinant Sequences

David Bryant, Daniel Huson, Thomas Kloepper, Kay Nieselt-Struwe 

Optimal DNA signal recognition models with a fixed amount of intrasignal dependency

Brona Brejova, Daniel G. Brown, Tomas Vinar 

A Method to detect alternative splicing by agreeing ESTs to a genomic sequence

Paola Bonizzoni, Graziano Pesole, Raffaella Rizzi

Homology Modeling of Proteins Using Multiple Models and Consensus Sequence Alignment

Jahnavi Prasad, Michael Silberstein, Carlos Camacho, Sandor Vajda 

Selecting Degenerate Multiplex PCR Primers

Richard Souvenir, Jeremy Buhler, Gary Stormo, Weixiong Zhang


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PROGRAM                                                                                                                                

16 September

*** Protein Structure ***

09.00-09.25
    Efficient Energy Computation for Monte Carlo Simulation of Proteins
    I. Lotan, F. Schwarzer, and J.-C. Latombe

09.25-09.50
    Speedup LP Approach to Protein Threading via Graph Reduction
    J. Xu

10.20-10.45
    Homology Modeling of Proteins Using Multiple Models and Consensus Sequence Alignment
    J. C. Prasad, M. Silberstein, C.J. Camacho, and S. Vajda

10.45-11.10
    Side-chain Structure Prediction Based on Dead-End Elimination:  Single Split DEE-criterion Implementation and Elimination Power
    J. A. Spriet

*** Phylogenetic Analysis ***

14.00-14.25
    Better Hill-Climbing Searches for Parsimony
    G. Ganapathy, V. Ramachandran, and T. Warnow

14.25-14.50
    Parsimonious Reconstruction of Sequence Evolution and Haplotype Blocks
    Y.S. Song and J. Hein

14.50-15.15
    Distance Corrections on Recombinant Sequences
    D. Bryant, D. Huson, T. Kloepper, and K. Nieselt-Struwe

15.45-16.10
    New Efficient Algorithm for Detection of Horizontal Gene Transfer Events
   
A. Boc and V. Makarenkov

16.10-16.35
    Efficient Generation of Uniform Samples from Phylogenetic Trees
   
P. Kearney, J. Ian Munro, and Derek Phillips

17 September

*** Sequence Alignment ***

09.00-09.25
    Large Version of the Small Parsimony Problem
   
J. Fredslund, J. Hein, and T. Scharling

09.25-09.50
    Optimal Multiple Parsimony Alignment with Affine Gap Cost Using a Phylogenetic Tree
   
B. Knudsen

*** Sequence Composition ***

10.20-10.45
    A Combinatorial Approach to Automatic Discovery of Cluster-Patterns
   
R. Eres, G. M. Landau, and L. Parida 

10.45-11.10
    Composition Alignment
   
G. Benson

*** Polymorphism ***

14.00-14.25
    Minimum Recombinant Haplotype Configuration on Tree Pedigrees
   
K. Doi J. Li, and T. Jiang

14.25-14.50
    Identifying Blocks and Sub-Populations in Noisy SNP Data
   
G. Kimmel, R. Sharan, and R. Shamir

14.50-15.15
    Designing Optimally Multiplexed SNP Genotyping Assays
   
Y. Aumann, E. Manisterski, and Z. Yakhini

*** Comparative Genomics ***

15.45-16.10
    A Local Chaining Algorithm and its Applications in Comparative Genomics
   
M. I. Abouelhoda and E. Ohlebusch

16.10-16.35
    Common Intervals of Two Sequences
   
G. Didier

18 September

*** Pattern and Motif Discovery ***

09.00-09.25
    Pattern Discovery Allowing Wild-Cards, Substitution Matrices and Multiple Score Functions
   
A. Mancheron and I. Rusu

09.25-09.50
    Dynamic Programming Algorithms for Two Statistical Problems in Computational Biology
   
S. Rahmann 

*** Database Searching ***

10.20-10.45
    Vector Seeds: An Extension to Spaced Seeds Allows Substantial Improvements in Sensitivity and Specificity
    B. Brejova, D.G. Brown, and T. Vinar

10.45-11.10
    A Systematic Statistical Analysis of Ion Trap Tandem Mass Spectra in View of Peptide Scoring
    J. Colinge, A. Masselot, and J. Magnin

*** Phylogeny ***

14.00-14.25
    Computing Refined Buneman Trees in Cubic Time
   
G. S. Brodal, R. Fagerberg, A. Ostlin, C. N. S. Pedersen, and S. S. Rao

14.25-14.50
    Ancestral Maximum Likelihood of Evolutionary Trees is Hard
   
L. Addario-Berry, B. Chor, M. Hallett, J. Lagergren, A. Panconesi, and T. Wareham

14.50-15.15
    Bayesian Phylogenetic Inference under a Statistical Insertion-deletion Model
   
G. Lunter, I. Miklos, A. Drummond, J.L. Jensen, and J. Hein

15.45-16.10
    Consensus Networks: A Method for Visualising Incompatibilities in Collections of Trees
   
B. Holland and V. Moulton

16.10-16.35
    A Linear-time Majority Tree Algorithm
   
N. Amenta, F. Clarke, and K. St. John

19 September

*** String Algorithms ***

09.00-09.25
    Match Chaining Algorithms for cDNA Mapping
   
T. Shibuya and I. Kurochkin

09.25-09.50
    Sequencing from Compomers: Using Mass Spectrometry for DNA de-novo Sequencing of 200+ nt
    S. Bocker

10.20-10.45
    Bounds for Resequencing By Hybridization
   
D. Tsur

10.45-11.10
    Selecting Degenerate Multiplex PCR Primers
   
R. Souvenir, J. Buhler, G. Stormo, and W. Zhang

*** Gene Finding and Expression ***

14.00-14.25
    A Method to Detect Gene Structure and Alternative Splice Sites by Agreeing ESTs to a Genomic Sequence
    P. Bonizzoni, G. Pesole, and R. Rizzi

14.25-14.50
    A Stochastic Approach to Count RNA Molecules Using DNA Sequencing Methods
   
B. Hollas and R. Schuler

14.50-15.15
    Optimal DNA Signal Recognition Models with a Fixed Amount of Intrasignal Dependency
   
B. Brejova, D. G. Brown, and T. Vinar

*** Genome Mapping ***

15.45-16.10
    Noisy Data Make the Partial Digest Problem NP-hard
    M. Cieliebak, S. Eidenbenz, and P. Penna

16.10-16.35
    New Algorithm for the Simplified Partial Digest Problem
   
J. Blazewicz and M. Jaroszewski

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IMPORTANT DATES                                                                                                                                

        Submission deadline: 28 April, 2003
        Notification to authors: 2 June, 2003
        Final version due: 30 June, 2003
        Symposium: 15-20 September, 2003

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PROGRAM COMMITTEE                                                                                                                         

        Amihood Amir (Bar Ilan University, Israel)
        Alberto Apostolico (Purdue University)
        Pierre Baldi (UC Irvine)
        Gary Benson (Mount Sinai School of Medicine, New York; Co-chair)
        Benny Chor (Tel Aviv University)
        Nadia El-Mabrouk (University of Montreal)
        Olivier Gascuel (LIRMM-CNRS, Montpellier)
        Raffaele Giancarlo (U. di Palermo)
        David Gilbert (University of Glasgow)
        Jan Gorodkin (The Royal Veterinary and Agricultural University, Denmark)
        Roderic Guigo (IMIM, Barcelona)
        Dan Gusfield (UC Davis)
        Jotun Hein (University of Oxford)
        Daniel Huson (Tübingen University)
        Simon Kasif (Boston University)
        Gregory Kucherov (INRIA-Lorraine/LORIA)
        Gad Landau (University of Haifa)
        Thierry Lecroq (Université de Rouen)
        Bernard M.E. Moret (U. New Mexico)
        Vincent Moulton (Uppsala University, Sweden)
        Roderic Page (University of Glasgow; Co-chair)
        Sophie Schbath (INRA, Jouy-en-Josas)
        Charles Semple (University of Canterbury, New Zealand)
        Jens Stoye (Universität Bielefeld)
        Fengzhu Sun (U. Southern California)
        Alfonso Valencia (Centro Nacional de Biotecnologia, Madrid)
        Jacques Van Helden (Université Libre de Bruxelles)
        Louxin Zhang (National University of Singapore)

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WABI STEERING COMMITTEE                                                                                                              

        Olivier Gascuel
        Raffaele Giancarlo
        Roderic Guigo
        Dan Gusfield
        Bernard Moret  


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